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48,xxxy is caused when nondisjunction errors occur in the development of the egg or sperm, resulting in a male inheriting two extra copies of the x.. Various anomalies can be found in this variant—more than other variants of klinefelters..

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About 48,xxxy 48,xxxy syndrome, also known as xxxy syndrome, is a less common x and y chromosome condition, affecting between 1 in 17,000 and 1 in 50,000 male births. The presence of one y chromosome with a functioning sry gene causes the expression of genes that determine maleness.
Xxxy syndrome is a genetic condition characterized by a sex chromosome aneuploidy, where individuals have two extra x chromosomes. View of rare sex chromosome aneuploidies 49,xxxxy.
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A case of xxxxy klinefelters syndrome. 48,xxxy is caused when nondisjunction errors occur in the development of the egg or sperm, resulting in a male inheriting two extra copies of the x.
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